5-METHYL-7-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID - Names and Identifiers
5-METHYL-7-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID - Physico-chemical Properties
Molecular Formula | C9H6F3N3O2
|
Molar Mass | 245.16 |
Density | 1.65±0.1 g/cm3(Predicted) |
pKa | -2.87±0.41(Predicted) |
Storage Condition | Room Temprature |
Sensitive | Irritant |
MDL | MFCD00480518 |
5-METHYL-7-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID - Risk and Safety
Hazard Symbols | Xi - Irritant
|
Hazard Class | IRRITANT |
5-METHYL-7-(TRIFLUOROMETHYL)PYRAZOLO[1,5-A]PYRIMIDINE-2-CARBOXYLIC ACID - Introduction
[1,5-a]-pyrimidine-2-carboxylic acid is an organic compound with the chemical formula C8H5F3N4O2. The following is a description of the properties, uses, preparation and safety information of this compound:
Nature:
-Appearance: White or off-white solid
-Melting point: about 165-168°C
-Solubility: Slightly soluble in water, soluble in some organic solvents such as dimethyl sulfoxide and dichloromethane
-Stability: Stable at room temperature
Use:
-[1,5-a]-pyrimidine-2-carboxylic acid is a pharmaceutical intermediate and organic synthetic reagent commonly used in the preparation of other organic compounds.
-It has potential anti-infective, antiviral and anti-inflammatory effects in the pharmaceutical field, so it is widely used in drug research and development.
Preparation Method:
[1,5-a]-The preparation method of pyrimidine-2-carboxylic acid involves a multi-step reaction. The following is a possible preparation route:
1. First, pyrazolo [1,5-a] pyrimidine -2-methanol is reacted with a trifluoromethylating reagent by a synthetic reaction to generate 5-methyl -7-(trifluoromethyl) pyrazolo [1,5-a] pyrimidine -2-methanol.
2. Then, 5-methyl -7-(trifluoromethyl) pyrazolo[1,5-a] pyrimidine-2-methanol is converted into the target product [1,5-a]-pyrimidine-2-carboxylic acid by dehydration reaction or other appropriate methods.
Safety Information:
-[1,5-a]-pyrimidine-2-carboxylic acid is generally relatively safe under normal conditions of use. However, there are exceptions, and for new chemicals it is recommended to follow strict safety practices.
-Wear appropriate protective equipment, such as laboratory gloves and safety goggles, during operation to avoid contact with skin and eyes.
-When storing and handling this compound, the container should be sealed and stored in a cool, dry and well-ventilated place.
-Read and understand relevant safety information and technical instructions prior to use and follow appropriate waste disposal regulations. In case of any doubt, it is recommended to consult a professional chemist or toxicologist.
Last Update:2024-04-09 21:01:54